The suspect, who is in his late teens, shot his grandmother and a younger female earlier in the day, police said. After which he ran into the Trader Joe's after crashing his grandmother's car outside the store during a police pursuit.
Eighteen ambulances and more than 100 firefighters were at the scene of the incident.
The suspect, described by police and witnesses as an African-American male, fled in a 2015 Toyota Camry, taking the younger victim with him. He fired multiple rounds at officers during the police pursuit, Lopez said. None of the officers was injured.
The chase ended when the suspect crashed the vehicle, got out and ran into the store on Hyperion Avenue in the Silver Lake neighborhood, Lopez said.
Customers immediately ran out of the store and police surrounded the building. Over the course of the standoff, several people walked out of the store with their hands up. Some employees climbed out a back window on a chain ladder.
Los Angeles Fire Department spokeswoman Margaret Stewart said a 20-year-old woman was transferred to a hospital in fair condition. She was removed from a vehicle, not the inside of the store, Stewart said. It was not immediately known whether that woman was the one from the original shooting.
Don Kohles, 91, told CNN he saw the car crash into a fire hydrant or a utility pole in front of the Trader Joe's.
"Then this guy comes out of the car and starts running toward TJs," Kohles said.
"I look behind me and there were two police guys coming with heavy guns, then boom boom boom boom, so I go into TJ's and I see this guy and he comes in.
"And I see the two front glass doors shot out. I look around and I see a TJ's employee laying on the ground, then all the help was laying on the ground," he said. The employee did not appear to be hurt, Kohles aid.
"We all laid there for about a half an hour until LAPD came and got us out. They helped carry me across the parking lot and they sort of tossed me over a wall," Kohles said.
Witness Devin Field said it appeared traffic prevented the suspect from escaping police when he crashed in front of the store.
The suspect had a pistol in his hand and
"just started opening fire on the police behind him," Field said. When police returned fire, Field and others got down on the ground, he said.
"After he was inside the store for a little while they had me crawl away from the scene and run away around the corner," Field said.
"He was very focused in getting out of the cops' vision," witness Miguel Trujillo said. "The exchange of bullets were all in an instant."
Public safety agencies responded in force, with an armored police vehicle parked outside the store and seven ambulances and dozens of law enforcement vehicles arriving on the scene.
Aerial video shot from a helicopter showed armed officers carrying shields and a man walking out with his hands up. It also showed officers carrying a person who appeared to be injured.
A manager at Gelson's Market, across the street from Trader Joe's, said people inside the market heard shots fired outside. Many people yelled and dropped to the floor, she said. The manager did not wish to give her name.
No one inside Gelson's was hurt to her knowledge. The store is currently on lockdown, but customers are allowed to exit through the back of the building.
CNN spoke to employees at nearby Jersey Mikes and What the Fish, both stores are on lockdown and no one was injured.
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